LXRX

LEXICON PHARMACEUTICALS, INC.

Nasdaq · Pharmaceutical Preparations · Inc. DE · CIK 0001062822
$1.92 +1.59% $852.9M
High Impact Filing (7/10)6 New Institutional Positions
Vol
Market Cap$852.9M
Cap SizeSmall Cap
Analyst ConsensusStrong Buy (73%)
Inst. Holders50 funds
Inst. Value$134.2M
Inst. Activity6 buys / 2 sells
Insider Activity4B / 0S
Insider Net $$369.7K
Reddit Sentiment50° Neutral
SEC Reports7
Press Releases3
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. DE·CIK 0001062822·Prev Close $1.89

Recent Activity

Jun 12, 2026 SEC
A mixed institutional cluster emerged in LXRX during Q3 2024: four asset managers (led by Legal & General Group doubling
INST-CLUSTER — Impact 5/10
Jun 11, 2026 SEC
A weak institutional cluster in LXRX shows 4 buyers (Schwab, Two Sigma, BofA, Morgan Stanley) adding $1.2M in aggregate
INST-CLUSTER — Impact 2/10
Jun 3, 2026 other
Lexicon to Present Data at the American Diabetes Association (ADA) 2026 Scientific Sessions
Presentations highlight consistent A1c reductions with sotagliflozin in type 1 diabetes and pharmaco
Jun 3, 2026 Insider
DEBBANE RAYMOND acquired via exercise 89,312 shares
Director
Jun 3, 2026 Insider
BARKER SAM L acquired via exercise 89,312 shares
Director
Jun 3, 2026 Insider
Amouyal Philippe acquired via exercise 89,312 shares
Director
May 6, 2026 SEC
Lexicon Pharmaceuticals entered into a $100 million loan facility with Hercules Capital, with $55 million funded at clos
8-K — Impact 4/10
Inst.
Point72 Asset Management, L.P. — DOUBLED
7,814,606 shares ($12.2M)

Price Targets

$3.77 +96.4% upside Strong Buy
Current $1.92 Low $1.75 Median $3.10 High $6.00 5 analysts
$1.75 $6.00

Analyst Ratings

Buy73% buy · 11 analysts
3Strong Buy
5Buy
3Hold
0Sell
0Strong Sell
Recent Analyst Actions
DateFirmActionRating
May 11, 2026 Citigroup MAINTAIN Buy → Buy
Mar 23, 2026 HC Wainwright & Co. REITERATE Buy → Buy
Mar 10, 2026 Citigroup MAINTAIN Buy → Buy
Mar 5, 2026 HC Wainwright & Co. MAINTAIN Buy → Buy

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $-0.05 $-0.06 — $-0.03 -602% YoY 5
Next Q $-0.06 $-0.07 — $-0.05 -49% YoY 5
Current FY $-0.16 $-0.18 — $-0.14 -13% YoY 5
Next FY $-0.21 $-0.27 — $-0.11 -30% YoY 5

Top Institutional Holders

FundValueMove
FMR LLC$70.3MTRIM
VANGUARD CAPITAL MANAGEMENT LLC$14.8M
Point72 Asset Management, L.P.$12.2MDOUBLED
BlackRock, Inc.$5.2M
MARSHALL WACE, LLP$3.7MADD

Recent Insider Trades

DateInsiderTypeValue
Jun 3, 2026DEBBANE RAYMONDM$0.00
Jun 3, 2026BARKER SAMM$0.00
Jun 3, 2026Amouyal PhilippeM$0.00
Jun 3, 2026Cheung IvanM$0.00
Jun 3, 2026Sullivan DianeM$0.00

Reddit Sentiment

50°
Neutral
Bearish Neutral Bullish
3 mentions 0 bullish 0 bearish
50 institutional holders with $134.2M total value (86,017,694 shares) as of 2026-Q1. Top holders: FMR, VANGUARD, Point72. Net buying activity: 6 institutions added/increased vs 2 reduced.

Top Institutional Holders — 2026-Q1

#FundSharesValue% of TrackedLast Move
1FMR LLC45,056,338$70.3M52.4%TRIM -33.5%
2VANGUARD CAPITAL MANAGEMENT LLC9,519,167$14.8M11.1%
3Point72 Asset Management, L.P.7,814,606$12.2M9.1%DOUBLED +2651.4%
4BlackRock, Inc.3,322,219$5.2M3.9%
5MARSHALL WACE, LLP2,376,304$3.7M2.8%ADD +88.2%
6SUSQUEHANNA INTERNATIONAL GROUP, LLP2,121,164$3.3M2.5%
7CIBC Bancorp USA Inc.1,800,000$2.8M2.1%
8RENAISSANCE TECHNOLOGIES LLC1,600,500$2.5M1.9%DOUBLED +508.0%
9VANGUARD FIDUCIARY TRUST CO1,332,284$2.1M1.5%
10CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,311,298$2.0M1.5%ADD +29.6%
11TWO SIGMA INVESTMENTS, LP1,199,632$1.9M1.4%ADD +38.4%
12CITADEL ADVISORS LLC1,094,901$1.7M1.3%
13GOLDMAN SACHS GROUP INC1,070,517$1.7M1.2%
14STATE STREET CORP964,038$1.5M1.1%TRIM -68.6%
15MACKENZIE FINANCIAL CORP772,677$1.2M0.9%
16SUSQUEHANNA INTERNATIONAL GROUP, LLP560,700$874.7K0.7%
17CITADEL ADVISORS LLC552,700$862.2K0.6%
18VANGUARD PORTFOLIO MANAGEMENT LLC546,600$852.7K0.6%
19BANK OF AMERICA CORP /DE/526,103$820.7K0.6%DOUBLED +415.3%
20Invesco Ltd.512,426$799.4K0.6%ADD +47.2%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
Point72 Asset Management, L.P.DOUBLED284,0257,814,606+2651.4%$12.2M2026-Q1
MARSHALL WACE, LLPADD1,262,3672,376,304+88.2%$3.7M2026-Q1
RENAISSANCE TECHNOLOGIES LLCDOUBLED263,2541,600,500+508.0%$2.5M2026-Q1
BANK OF AMERICA CORP /DE/DOUBLED102,097526,103+415.3%$820.7K2026-Q1
Hudson Bay Capital Management LPADD100,532152,616+51.8%$238.1K2026-Q1
OMERS ADMINISTRATION CorpTRIM273,800106,800-61.0%$166.6K2026-Q1
ExodusPoint Capital Management, LPNEAR_EXIT268,43337,430-86.1%$58.4K2026-Q1
CAPTRUST FINANCIAL ADVISORSADD11,73515,450+31.7%$24.1K2026-Q1
BANK OF AMERICA CORP /DE/ADD57,804102,097+76.6%$117.4K2025-Q4
WEALTH ENHANCEMENT ADVISORY SERVICES, LLCTRIM18,87713,520-28.4%$15.4K2025-Q4
HRT FINANCIAL LPDOUBLED46,447117,549+153.1%$135.002025-Q4
CWM, LLCTRIM26,74413,179-50.7%$15.002025-Q4
WELLS FARGO & COMPANY/MNNEAR_EXIT3011-99.7%$1.002025-Q4
CHARLES SCHWAB INVESTMENT MANAGEMENT INCADD883,2271,144,632+29.6%$1.5M2025-Q3
TWO SIGMA INVESTMENTS, LPADD403,922559,008+38.4%$754.7K2025-Q3
GROUP ONE TRADING LLCTRIM346,752216,244-37.6%$291.9K2025-Q3
MORGAN STANLEYADD131,393169,018+28.6%$228.2K2025-Q3
BANK OF MONTREAL /CAN/TRIM100,00070,000-30.0%$94.5K2025-Q3
BANK OF AMERICA CORP /DE/ADD32,09757,804+80.1%$78.0K2025-Q3
WEALTH ENHANCEMENT ADVISORY SERVICES, LLCTRIM74,45418,877-74.6%$28.7K2025-Q3
CAPTRUST FINANCIAL ADVISORSTRIM35,58214,069-60.5%$19.0K2025-Q3
WELLS FARGO & COMPANY/MNNEAR_EXIT26,423301-98.9%$406.002025-Q3
HRT FINANCIAL LPNEAR_EXIT488,46846,447-90.5%$62.002025-Q3
COMMONWEALTH EQUITY SERVICES, LLCTRIM90,86435,738-60.7%$48.002025-Q3
CWM, LLCNEAR_EXIT109,33026,744-75.5%$36.002025-Q3
16 unique insiders with 50 transactions. Net insider value: $369.7K ($369.7K bought, $0.00 sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 3, 2026DEBBANE RAYMONDDirectorEXERCISE89,312
Jun 3, 2026BARKER SAM LDirectorEXERCISE89,312
Jun 3, 2026Amouyal PhilippeDirectorEXERCISE89,312
Jun 3, 2026Cheung IvanDirectorEXERCISE89,312
Jun 3, 2026Sullivan Diane E.DirectorEXERCISE89,312
Jun 3, 2026SOBECKI CHRISTOPHER JDirectorEXERCISE89,312
Jun 3, 2026Swain Judith LDirectorEXERCISE89,312
May 1, 2026DEBBANE RAYMONDDirectorAWARD35,714
May 1, 2026DEBBANE RAYMONDDirectorAWARD43,478
May 1, 2026Swain Judith LDirectorAWARD35,714
May 1, 2026Swain Judith LDirectorAWARD43,478
May 1, 2026Cheung IvanDirectorAWARD35,714
May 1, 2026Cheung IvanDirectorAWARD43,478
May 1, 2026BARKER SAM LDirectorAWARD35,714
May 1, 2026BARKER SAM LDirectorAWARD43,478
May 1, 2026SOBECKI CHRISTOPHER JDirectorAWARD35,714
May 1, 2026SOBECKI CHRISTOPHER JDirectorAWARD43,478
May 1, 2026Amouyal PhilippeDirectorAWARD35,714
May 1, 2026Amouyal PhilippeDirectorAWARD43,478
Apr 30, 2026Artal Participations S.a r.l.DirectorEXERCISE408,434.7
Apr 30, 2026Artal Participations S.a r.l.DirectorAWARD408,434.7
Apr 30, 2026Artal Participations S.a r.l.DirectorEXERCISE20,421,735
Feb 28, 2026Martens Rachel YapSVP, Partnerships & Corp StratEXERCISE67,090
Feb 28, 2026Gopinathan SumaSVP, DiscoveryEXERCISE14,000
Feb 28, 2026Crum Brian TSVP, General Counsel & Secr.EXERCISE33,457
Feb 28, 2026Exton MichaelChief Executive OfficerEXERCISE503,263
Feb 28, 2026DeFrancesco LisaSVP, IR and Corp CommEXERCISE24,674
Feb 28, 2026McDermott WendySVP, Human ResourcesEXERCISE27,697
Feb 28, 2026Granowitz Craig BSVP, Chief Medical OfficerEXERCISE35,790
Feb 28, 2026Crum Brian TSVP, General Counsel & Secr.EXERCISE69,386
Feb 28, 2026Coiante Scott MSVP, Chief Financial OfficerEXERCISE160,237
Feb 25, 2026DEBBANE RAYMONDDirectorBUY2,000$1.49$3.0K
Feb 23, 2026DEBBANE RAYMONDDirectorBUY100,000$1.47$147.0K
Feb 20, 2026DEBBANE RAYMONDDirectorBUY100,000$1.48$147.8K
Feb 19, 2026DEBBANE RAYMONDDirectorBUY50,000$1.44$72.0K
Feb 12, 2026DeFrancesco LisaSVP, IR and Corp CommAWARD257,530
Feb 12, 2026DeFrancesco LisaSVP, IR and Corp CommAWARD386,300
Feb 12, 2026Exton MichaelChief Executive OfficerAWARD862,440
Feb 12, 2026Exton MichaelChief Executive OfficerAWARD1,293,670
Feb 12, 2026Gopinathan SumaSVP, DiscoveryAWARD238,450
Feb 12, 2026Gopinathan SumaSVP, DiscoveryAWARD357,680
Feb 12, 2026Coiante Scott MSVP, Chief Financial OfficerAWARD272,680
Feb 12, 2026Coiante Scott MSVP, Chief Financial OfficerAWARD409,020
Feb 12, 2026Granowitz Craig BSVP, Chief Medical OfficerAWARD346,610
Feb 12, 2026Granowitz Craig BSVP, Chief Medical OfficerAWARD519,920
Feb 12, 2026Crum Brian TSVP, General Counsel & Secr.AWARD299,710
Feb 12, 2026Crum Brian TSVP, General Counsel & Secr.AWARD449,560
Feb 12, 2026McDermott WendySVP, Human ResourcesAWARD250,200
Feb 12, 2026McDermott WendySVP, Human ResourcesAWARD375,300
Feb 12, 2026Martens Rachel YapSVP, Partnerships & Corp StratAWARD193,740
Current analyst consensus: Buy (73% buy). Based on 11 analysts: 3 strong buy, 5 buy, 3 hold, 0 sell, 0 strong sell.

Analyst Price Targets

$3.77 mean target +96.4% upside Strong Buy (2.00)
$1.75 Low $6.00 High
MetricValue
Current Price$1.92
Target Low$1.75
Target Mean$3.77
Target Median$3.10
Target High$6.00
# Analysts5
RecommendationStrong Buy (2.00)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$-0.05 $-0.06 $-0.03 -602.3% +0.0% $0.0B -86.2% 5
Next Q
2026-09-30
$-0.06 $-0.07 $-0.05 -48.9% +0.0% $0.0B -78.3% 5
Current FY
2026-12-31
$-0.16 $-0.18 $-0.14 -13.3% +0.0% 2↑ 0↓ $0.0B -23.4% 5
Next FY
2027-12-31
$-0.21 $-0.27 $-0.11 -30.0% +0.0% 0↑ 1↓ $0.0B -47.2% 5

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$-0.050
7d ago$-0.050
30d ago$-0.050
60d ago$-0.055+0.005
90d ago$-0.055+0.005
2 analyst firms have rated this stock: 0 upgrades, 0 downgrades, 0 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
May 11, 2026 Citigroup MAINTAIN Buy Buy
Mar 23, 2026 HC Wainwright & Co. REITERATE Buy Buy
Mar 10, 2026 Citigroup MAINTAIN Buy Buy
Mar 5, 2026 HC Wainwright & Co. MAINTAIN Buy Buy

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 20263530073%
May 1, 20263530073%
Apr 1, 20263530073%
Mar 1, 20263530073%
Feb 1, 20263530073%
Jan 1, 20263530073%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

50°
Neutral
Bearish Neutral Bullish
3 mentions 0 bullish 0 bearish 3 time periods

Reddit Sentiment History

DateMentionsSentimentBullishBearishThreads
Apr 12, 2026150° Neutral001
Apr 12, 2026150° Neutral001
Feb 19, 2026150° Neutral001

Recent Reddit Threads

r/pennystocks Neutral 2mo ago
TMC Penny Stock Punchcard Video 4-11-2026 (FUBO, DVLT, LXRX, SIDU, SMRT)
▲ 1 💬 1 ⚡ 0.5
r/pennystocks Neutral 3mo ago
LXRX set to spike
▲ 1 💬 0 ⚡ 0.0
Jun 3, 2026
other
Lexicon to Present Data at the American Diabetes Association (ADA) 2026 Scientific Sessions
Presentations highlight consistent A1c reductions with sotagliflozin in type 1 diabetes and pharmacokinetics of pilavapadin across renal function grou
May 28, 2026
other
Lexicon Pharmaceuticals to Present at the 2026 Jefferies Global Healthcare Conference
<p align="left">THE WOODLANDS, Texas, May 28, 2026 (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=Jg-AJURJmAVl73VhxWU7Kgpw_
May 7, 2026
earnings
Lexicon Pharmaceuticals Reports First Quarter 2026 Financial Results and Provides Clinical Updates
<p align="center"><strong><em>SONATA-HCM anticipated to be fully enrolled mid-2026 </em></strong></p>
May 7, 2026
earnings_calendar
LXRX Q1 2026 Earnings Scheduled — 2026-05-07
May 1, 2026
short_volume
Short Volume: LXRX — 59.3% short (0.4M / 0.7M)
Short: 387,102 | Exempt: 0 | TRF Vol: 652,750 | Short Ratio: 59.3% | Off-exchange volume (dark pool + OTC)
Apr 30, 2026
earnings
Lexicon Pharmaceuticals to Report First Quarter 2026 Financial Results on May 7, 2026
<p align="left">THE WOODLANDS, Texas, April 30, 2026 (GLOBE NEWSWIRE) -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) today announced the Company wi
Apr 30, 2026
earnings_calendar
LXRX Q1 2026 Earnings Scheduled — 2026-04-30
Apr 22, 2026
Enforcement
HSR Early Termination: Stichting Administratiekantoor Westend; Lexicon Pharmaceuticals, Inc.
The FTC granted early termination of the HSR Act waiting period for a transaction involving Stichting Administratiekantoor Westend; Lexicon Pharmaceut
Apr 17, 2026
routine
Lexicon to Present Data at the American Academy of Neurology (AAN) Annual Meeting
<p align="center"><em> Oral presentation highlights additional data from PROGRESS Phase 2b study of pilavapadin supporting selection of 10mg as optima
Apr 6, 2026
short_volume
Short Volume: LXRX — 63.0% short (0.5M / 0.8M)
Short: 481,359 | Exempt: 1 | TRF Vol: 764,472 | Short Ratio: 63.0% | Off-exchange volume (dark pool + OTC)
Apr 2, 2026
short_volume
Short Volume: LXRX — 71.1% short (0.9M / 1.2M)
Short: 851,241 | Exempt: 30 | TRF Vol: 1,196,609 | Short Ratio: 71.1% | Off-exchange volume (dark pool + OTC)
Mar 24, 2026
fda
Lexicon Announces Three Presentations at the American College of Cardiology (ACC) Annual Scientific Session & Expo
Additional analyses from the SCORED and SOTA-P-CARDIA studies provide further evidence of benefits across patient subgroups potentially related to sot
Mar 23, 2026
fda
Lexicon Pharmaceuticals and Novo Nordisk Announce initiation of Phase 1 study with oral obesity drug candidate LX9851
<p align="center"><em>LX9851 is a first-in-class, oral non-incretin candidate being developed by Novo Nordisk for the treatment of obesity and associa
Mar 5, 2026
earnings
Lexicon Pharmaceuticals Reports Fourth Quarter 2025 Financial Results and Provides Clinical Updates
<p align="center"><strong><em>Pivotal sotagliflozin milestones on schedule including resubmission of NDA in T1D and enrollment of SONATA study for HCM
Mar 5, 2026
earnings_calendar
LXRX Q4 2025 Earnings After Market Close — 2026-03-05
Mar 3, 2026
other
Lexicon Pharmaceuticals to Participate in Three Upcoming March Investor Conferences
<p align="left">THE WOODLANDS, Texas, March 03, 2026 (GLOBE NEWSWIRE) -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) today announced that Company m