INSM

INSMED Inc

Nasdaq · Pharmaceutical Preparations · Inc. VA · CIK 0001104506
$107.18 -2.15% $23.7B
Insider Selling Cluster (5 insiders)High Impact Filing (9/10)
Vol
Market Cap$23.7B
Cap SizeLarge Cap
Analyst ConsensusStrong Buy (96%)
Inst. Holders10 funds
Inst. Value$6.9B
Inst. Activity2 buys / 2 sells
Insider Activity0B / 18S
Insider Net $-$13.3M
SEC Reports17
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. VA·CIK 0001104506·Prev Close $109.53

Recent Activity

May 21, 2026 short_volume
Short Volume: INSM — 58.7% short (0.7M / 1.2M)
Short: 730,482 | Exempt: 25 | TRF Vol: 1,244,669 | Short Ratio: 58.7% | Off-exchange volume (dark po
May 18, 2026 Insider
Lewis William sold 6,259 shares
Chair and CEO @ $30.46 ($190.6K)
May 18, 2026 Insider
Lewis William sold 5,753 shares
Chair and CEO @ $105.32 ($605.9K)
May 18, 2026 Insider
Lewis William sold 6,259 shares
Chair and CEO @ $0.00 ($0.00)
May 16, 2026 SEC
Morgan Stanley upgrades INSM to Overweight — PT $212 (+94%) as part of 7-firm cluster
ANALYST-UPGRADE — Impact 5/10
Apr 16, 2026 SEC
Barclays initiates coverage on INSM with an Overweight rating and $231 price target, implying 44% upside from the curren
ANALYST-UPGRADE — Impact 8/10
Apr 16, 2026 SEC
Morgan Stanley initiated a double upgrade to Overweight from Equal-Weight with a $212 price target, implying 32.3% upsid
ANALYST-UPGRADE — Impact 9/10
Inst.
NORGES BANK — NEW
2,910,971 shares ($506.6M)

Price Targets

$200.00 +86.6% upside Strong Buy
Current $107.18 Low $140.00 Median $205.00 High $243.00 21 analysts
$140.00 $243.00

Analyst Ratings

Strong Buy96% buy · 28 analysts
9Strong Buy
18Buy
1Hold
0Sell
0Strong Sell
Recent Analyst Actions
DateFirmActionRating
May 14, 2026 Truist Securities MAINTAIN Buy → Buy
May 8, 2026 RBC Capital MAINTAIN Outperform → Outperform
May 8, 2026 Wells Fargo MAINTAIN Overweight → Overweight
May 8, 2026 Guggenheim MAINTAIN Buy → Buy
Apr 17, 2026 Roth Capital REITERATE Buy → Buy

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $-0.77 ▲ +1.6% $-1.09 — $-0.58 55% YoY 13
Next Q $-0.60 ▼ -3.3% $-1.14 — $-0.35 66% YoY 13
Current FY $-2.74 ▲ +1.9% $-4.29 — $-1.84 57% YoY 14
Next FY $0.40 ▼ -46.0% $-1.91 — $1.64 115% YoY 15

Top Institutional Holders

FundValueMove
VANGUARD GROUP INC$3.7B
FMR LLC$1.7BADD
NORGES BANK$506.6MNEW
BANK OF AMERICA CORP$300.3MADD
MORGAN STANLEY$284.0MADD

Recent Insider Trades

DateInsiderTypeValue
May 18, 2026Lewis WilliamM$190.6K
May 18, 2026Lewis WilliamSELL$605.9K
May 18, 2026Lewis WilliamM$0.00
May 14, 2026Flammer MartinaSELL$1.2M
May 13, 2026Flammer MartinaSELL$504.0K
10 institutional holders with $6.9B total value (41,356,652 shares) as of 2025-Q4. Top holders: VANGUARD, FMR, NORGES.

Top Institutional Holders — 2025-Q4

#FundSharesValue% of TrackedLast Move
1VANGUARD GROUP INC21,076,344$3.7B52.9%
2FMR LLC9,927,936$1.7B24.9%ADD +80.3%
3NORGES BANK2,910,971$506.6M7.3%NEW
4BANK OF AMERICA CORP /DE/1,725,681$300.3M4.3%ADD +61.1%
5MORGAN STANLEY1,631,906$284.0M4.1%ADD +69.3%
6CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,027,355$178.8M2.6%NEW
7TWO SIGMA INVESTMENTS, LP962,156$167.5M2.4%DOUBLED +105.2%
8WELLS FARGO & COMPANY/MN586,651$102.1M1.5%ADD +98.2%
9RENAISSANCE TECHNOLOGIES LLC25,900$4.5M0.1%NEAR_EXIT -92.7%
10Duquesne Family Office LLC1,481,752$257.9K0.0%TRIM -38.9%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
NORGES BANKNEW2,910,971$506.6M2025-Q4
MORGAN STANLEYADD963,6311,631,906+69.3%$284.0M2025-Q4
RENAISSANCE TECHNOLOGIES LLCNEAR_EXIT352,88725,900-92.7%$4.5M2025-Q4
Duquesne Family Office LLCTRIM2,423,4351,481,752-38.9%$257.9K2025-Q4
FMR LLCADD5,093,2619,180,963+80.3%$1.3B2025-Q3
BANK OF AMERICA CORP /DE/ADD1,251,3372,016,406+61.1%$290.4M2025-Q3
UBS Group AGDOUBLED383,4541,732,039+351.7%$249.4M2025-Q3
TWO SIGMA INVESTMENTS, LPDOUBLED376,508772,780+105.2%$111.3M2025-Q3
WELLS FARGO & COMPANY/MNADD259,207513,849+98.2%$74.0M2025-Q3
NORGES BANKEXIT1,934,8990-100.0%$0.002025-Q3
FMR LLCADD3,394,3845,093,261+50.0%$512.6M2025-Q2
NORGES BANKNEW1,934,899$194.7M2025-Q2
RENAISSANCE TECHNOLOGIES LLCNEW308,687$31.1M2025-Q2
WELLS FARGO & COMPANY/MNADD205,511259,207+26.1%$26.1M2025-Q2
Duquesne Family Office LLCADD1,369,0502,353,435+71.9%$236.8K2025-Q2
FMR LLCTRIM4,856,2493,394,384-30.1%$259.0M2025-Q1
TWO SIGMA INVESTMENTS, LPTRIM593,996406,903-31.5%$31.0M2025-Q1
WELLS FARGO & COMPANY/MNADD160,709205,511+27.9%$15.7M2025-Q1
Duquesne Family Office LLCDOUBLED593,4701,369,050+130.7%$104.4K2025-Q1
RENAISSANCE TECHNOLOGIES LLCEXIT25,2870-100.0%$0.002025-Q1
NORGES BANKEXIT1,833,8100-100.0%$0.002025-Q1
WELLS FARGO & COMPANY/MNADD127,495160,709+26.1%$11.1M2024-Q4
RENAISSANCE TECHNOLOGIES LLCNEW25,287$1.7M2024-Q4
Duquesne Family Office LLCDOUBLED20,000593,470+2867.4%$41.0K2024-Q4
CHARLES SCHWAB INVESTMENT MANAGEMENT INCNEW1,444,266$105.4M2024-Q3
12 unique insiders with 18 transactions. Net insider value: -$13.3M ($0.00 bought, $13.3M sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
May 18, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
May 18, 2026Lewis WilliamChair and CEOSELL5,753$105.32$605.9K
May 18, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
May 14, 2026Flammer Martina M.D.Chief Medical OfficerSELL10,479$117.54$1.2M
May 13, 2026Flammer Martina M.D.Chief Medical OfficerSELL4,470$112.76$504.0K
May 13, 2026Smith Michael AlexanderChief Legal OfficerSELL4,109$116.18$477.4K
May 13, 2026SHAROKY MELVIN MDDirectorA3,305$0.00$0.00
May 13, 2026Adsett RogerChief Operating OfficerSELL5,837$116.18$678.1K
May 13, 2026Brennan David RDirectorA3,305$0.00$0.00
May 13, 2026Desjardins ClarissaDirectorA3,305$0.00$0.00
May 13, 2026LEE LEODirectorA3,305$0.00$0.00
May 13, 2026Lewis WilliamChair and CEOSELL13,283$116.18$1.5M
May 13, 2026ANDERSON ELIZABETH MDirectorA3,305$0.00$0.00
May 13, 2026Bonstein SaraChief Financial OfficerSELL8,272$116.18$961.0K
May 13, 2026SCHAFER CAROLDirectorA3,305$0.00$0.00
May 11, 2026Flammer Martina M.D.Chief Medical OfficerM12,949$17.07$221.0K
May 11, 2026Flammer Martina M.D.Chief Medical OfficerSELL12,119$100.35$1.2M
May 11, 2026Flammer Martina M.D.Chief Medical OfficerM12,949$0.00$0.00
May 4, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
May 4, 2026Lewis WilliamChair and CEOSELL433$134.18$58.1K
May 4, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
Apr 16, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
Apr 16, 2026Lewis WilliamChair and CEOSELL2,246$142.99$321.2K
Apr 16, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
Apr 6, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
Apr 6, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
Apr 6, 2026Lewis WilliamChair and CEOSELL787$161.73$127.3K
Apr 1, 2026Adsett RogerChief Operating OfficerM88,060$14.56$1.3M
Apr 1, 2026Adsett RogerChief Operating OfficerSELL6,715$163.18$1.1M
Apr 1, 2026Adsett RogerChief Operating OfficerM88,060$0.00$0.00
Mar 30, 2026Smith Michael AlexanderChief Legal OfficerSELL19,638$150.98$3.0M
Mar 30, 2026Smith Michael AlexanderChief Legal OfficerM5,649$17.07$96.4K
Mar 30, 2026Smith Michael AlexanderChief Legal OfficerM5,649$0.00$0.00
Mar 19, 2026Lewis WilliamChair and CEOSELL1,629$142.17$231.6K
Mar 19, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
Mar 19, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
Mar 5, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
Mar 5, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
Mar 3, 2026SHAROKY MELVIN MDDirectorG100$0.00$0.00
Feb 25, 2026SHAROKY MELVIN MDDirectorG1,072$0.00$0.00
Feb 23, 2026Brennan David RDirectorG6,000$0.00$0.00
Feb 19, 2026Lewis WilliamChair and CEOM6,259$30.46$190.6K
Feb 19, 2026Lewis WilliamChair and CEOSELL1,988$149.17$296.5K
Feb 19, 2026Lewis WilliamChair and CEOM6,259$0.00$0.00
Feb 9, 2026Lewis WilliamChair and CEOM4,440$0.00$0.00
Feb 9, 2026Lewis WilliamChair and CEOSELL4,888$147.17$719.4K
Feb 9, 2026Lewis WilliamChair and CEOM4,440$17.16$76.2K
Feb 9, 2026MCGIRR DAVID W JDirectorG53,400$0.00$0.00
Feb 5, 2026Flammer Martina M.D.Chief Medical OfficerSELL869$152.44$132.5K
Feb 3, 2026Adsett RogerChief Operating OfficerSELL791$156.17$123.5K
17 SEC filing reports analyzed. Sentiment: 5 bullish, 3 bearish, 4 mixed, 5 neutral. Avg impact: 5.3/10.
BULLISH ANALYST-UPGRADE 5/10
Morgan Stanley upgrades INSM to Overweight — PT $212 (+94%) as part of 7-firm cluster
May 16, 2026
BULLISH ANALYST-UPGRADE 9/10
Morgan Stanley initiated a double upgrade to Overweight from Equal-Weight with a $212 price target,
Apr 16, 2026
BULLISH ANALYST-UPGRADE 8/10
Barclays initiates coverage on INSM with an Overweight rating and $231 price target, implying 44% up
Apr 16, 2026
BULLISH ANALYST-UPGRADE 7/10
Roth Capital initiates coverage on INSM with a Buy rating and $212 price target, implying 32.3% upsi
Apr 16, 2026
MIXED ANALYST-UPGRADE 6/10
William Blair initiates coverage on INSM with an Outperform rating, adding to recent momentum that i
Apr 16, 2026
MIXED ANALYST-UPGRADE 5/10
Jefferies initiates INSM with a Buy rating and $105 price target, below the $160.18 current price an
Apr 16, 2026
MIXED ANALYST-UPGRADE 6/10
RBC Capital initiates coverage on INSM with Outperform and a $100 price target, below the $214.79 me
Apr 16, 2026
MIXED ANALYST-UPGRADE 5/10
Truist Securities initiates coverage on INSM with a Buy rating and $48 price target, below the $214.
Apr 16, 2026
NEUTRAL S-3ASR 3/10
Insmed filed an automatic shelf registration (S-3ASR) covering an indeterminate amount of common sto
May 15, 2026
NEUTRAL CLUSTER 3/10
Two C-suite insiders (CMO and CLO) sold a total of ~$981K worth of INSM shares, representing a trivi
May 15, 2026
NEUTRAL 144 2/10
Sara Bonstein, an officer of Insmed, filed a Form 144 on May 13, 2026, indicating intent to sell 8,2
May 13, 2026
NEUTRAL CLUSTER 3/10
Insmed's CEO and CMO sold a combined $1.27M in stock within a week of a strong Q1 2026 earnings beat
May 13, 2026
BULLISH 8-K 6/10
Insmed reported Q1 2026 total revenue of $306.0M (up 230% YoY, driven by BRINSUPRI launch) and a net
May 7, 2026
BEARISH CLUSTER 7/10
Two C-suite executives at INSMED Inc sold shares in early April, generating $4.06M in open-market pr
Apr 8, 2026
BEARISH 8-K 7/10
Insmed announced that its Phase 2b CEDAR study of brensocatib in hidradenitis suppurativa (HS) faile
Apr 7, 2026
BEARISH CLUSTER 5/10
Two C-suite executives at Insmed sold shares in the past week, generating $4.06 million in total pro
Apr 3, 2026
NEUTRAL DEFA14A 3/10
Analysis based on filing metadata only — document content was unavailable
Apr 1, 2026

No press releases analyzed yet. Press releases are collected from GlobeNewsWire and analyzed by the LLM pipeline.

Current analyst consensus: Strong Buy (96% buy). Based on 28 analysts: 9 strong buy, 18 buy, 1 hold, 0 sell, 0 strong sell.

Analyst Price Targets

$200.00 mean target +86.6% upside Strong Buy (1.23)
$140.00 Low $243.00 High
MetricValue
Current Price$107.18
Target Low$140.00
Target Mean$200.00
Target Median$205.00
Target High$243.00
# Analysts21
RecommendationStrong Buy (1.23)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$-0.77 $-1.09 $-0.58 54.6% +1.6% 4↑ 6↓ $0.4B 265.1% 13
Next Q
2026-09-30
$-0.60 $-1.14 $-0.35 66.0% -3.3% 4↑ 7↓ $0.5B 228.0% 13
Current FY
2026-12-31
$-2.74 $-4.29 $-1.84 57.3% +1.9% 5↑ 8↓ $1.7B 180.3% 14
Next FY
2027-12-31
$0.40 $-1.91 $1.64 114.7% -46.0% 3↑ 10↓ $2.8B 64.8% 15

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$-0.772
7d ago$-0.775+0.003
30d ago$-0.784+0.012
60d ago$-0.868+0.097
90d ago$-0.825+0.053
16 analyst firms have rated this stock: 1 upgrades, 0 downgrades, 2 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
May 14, 2026 Truist Securities MAINTAIN Buy Buy
May 8, 2026 RBC Capital MAINTAIN Outperform Outperform
May 8, 2026 Wells Fargo MAINTAIN Overweight Overweight
May 8, 2026 Guggenheim MAINTAIN Buy Buy
Apr 17, 2026 Roth Capital REITERATE Buy Buy
Apr 14, 2026 RBC Capital MAINTAIN Outperform Outperform
Apr 1, 2026 Barclays MAINTAIN Overweight Overweight
Mar 30, 2026 Morgan Stanley UPGRADE Equal-Weight Overweight
Mar 26, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Mar 25, 2026 Mizuho MAINTAIN Outperform Outperform
Mar 24, 2026 Leerink Partners MAINTAIN Outperform Outperform
Mar 24, 2026 Stifel MAINTAIN Buy Buy
Mar 24, 2026 Wells Fargo MAINTAIN Overweight Overweight
Mar 24, 2026 B of A Securities MAINTAIN Buy Buy
Mar 23, 2026 Wells Fargo MAINTAIN Overweight Overweight
Feb 24, 2026 Mizuho MAINTAIN Outperform Outperform
Feb 23, 2026 HC Wainwright & Co. REITERATE Buy Buy
Feb 20, 2026 Wells Fargo MAINTAIN Overweight Overweight
Jan 30, 2026 Morgan Stanley MAINTAIN Equal-Weight Equal-Weight
Jan 28, 2026 Barclays INITIATE Overweight
Jan 23, 2026 Roth Capital INITIATE Buy
Jan 21, 2026 RBC Capital MAINTAIN Outperform Outperform
Jan 6, 2026 UBS MAINTAIN Buy Buy
Dec 18, 2025 TD Cowen MAINTAIN Buy Buy
Dec 18, 2025 Goldman Sachs MAINTAIN Buy Buy
Dec 18, 2025 HC Wainwright & Co. MAINTAIN Buy Buy
Dec 18, 2025 Guggenheim MAINTAIN Buy Buy
Dec 18, 2025 RBC Capital MAINTAIN Outperform Outperform
Dec 16, 2025 Wells Fargo MAINTAIN Overweight Overweight
Dec 16, 2025 Cantor Fitzgerald MAINTAIN Overweight Overweight
Dec 15, 2025 Goldman Sachs MAINTAIN Buy Buy
Dec 11, 2025 TD Cowen MAINTAIN Buy Buy
Dec 1, 2025 Mizuho MAINTAIN Outperform Outperform

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
May 1, 202691810096%
Apr 1, 202691610096%
Mar 1, 202691520092%
Feb 1, 202691620093%
Jan 1, 202691420092%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

No Reddit sentiment data available yet. Sentiment is analyzed from Reddit investment communities on a rolling basis.

May 21, 2026
short_volume
Short Volume: INSM — 58.7% short (0.7M / 1.2M)
Short: 730,482 | Exempt: 25 | TRF Vol: 1,244,669 | Short Ratio: 58.7% | Off-exchange volume (dark pool + OTC)
May 14, 2026
short_volume
Short Volume: INSM — 64.2% short (0.7M / 1.1M)
Short: 709,665 | Exempt: 334 | TRF Vol: 1,105,731 | Short Ratio: 64.2% | Off-exchange volume (dark pool + OTC)
May 13, 2026
short_volume
Short Volume: INSM — 57.7% short (1.6M / 2.8M)
Short: 1,603,238 | Exempt: 13 | TRF Vol: 2,780,528 | Short Ratio: 57.7% | Off-exchange volume (dark pool + OTC)
May 7, 2026
earnings_calendar
INSM Q1 2026 Earnings Scheduled — 2026-05-07
May 6, 2026
short_volume
Short Volume: INSM — 62.3% short (0.5M / 0.8M)
Short: 476,618 | Exempt: 4,259 | TRF Vol: 765,237 | Short Ratio: 62.3% | Off-exchange volume (dark pool + OTC)
May 4, 2026
short_volume
Short Volume: INSM — 62.7% short (0.5M / 0.8M)
Short: 512,502 | Exempt: 90 | TRF Vol: 817,702 | Short Ratio: 62.7% | Off-exchange volume (dark pool + OTC)
Apr 28, 2026
short_volume
Short Volume: INSM — 56.2% short (0.3M / 0.5M)
Short: 298,836 | Exempt: 386 | TRF Vol: 531,317 | Short Ratio: 56.2% | Off-exchange volume (dark pool + OTC)
Apr 27, 2026
dark_pool
Dark Pool: INSM — 2.2M shares, 51,517 trades
Week starting 2026-04-27. Total ATS volume: 2,214,643 shares across 51,517 trades.
Apr 24, 2026
short_volume
Short Volume: INSM — 57.5% short (0.7M / 1.2M)
Short: 666,641 | Exempt: 2,338 | TRF Vol: 1,158,860 | Short Ratio: 57.5% | Off-exchange volume (dark pool + OTC)
Apr 23, 2026
Clinical Trial
An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Phase Phase 3 — COMPLETED
Apr 23, 2026
clinical_trial_readout
Results Pending: Treprostinil Palmitil Inhalation Powder (Phase 3) — Completed 22d ago
Trial: An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-I
Apr 23, 2026
short_volume
Short Volume: INSM — 74.6% short (0.4M / 0.5M)
Short: 377,337 | Exempt: 410 | TRF Vol: 505,497 | Short Ratio: 74.6% | Off-exchange volume (dark pool + OTC)
Apr 22, 2026
short_volume
Short Volume: INSM — 76.8% short (0.5M / 0.6M)
Short: 482,491 | Exempt: 0 | TRF Vol: 627,927 | Short Ratio: 76.8% | Off-exchange volume (dark pool + OTC)
Apr 21, 2026
short_volume
Short Volume: INSM — 81.0% short (0.5M / 0.7M)
Short: 534,270 | Exempt: 0 | TRF Vol: 659,294 | Short Ratio: 81.0% | Off-exchange volume (dark pool + OTC)
Apr 20, 2026
dark_pool
Dark Pool: INSM — 2.8M shares, 49,186 trades
Week starting 2026-04-20. Total ATS volume: 2,762,941 shares across 49,186 trades.
Apr 20, 2026
short_interest
FTD: INSM — 139,933 shares ($20.2M) failed to deliver
Settlement: 20260420, Price: $144.48, FTD Value: $20,217,519.84, INSMED INC-NEW
Apr 1, 2026
Clinical Trial
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension
Phase Phase 2 — COMPLETED
Mar 12, 2026
Clinical Trial
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Brensocatib Tablets in Adults With Cystic Fibrosis
Phase Phase 2 — COMPLETED
Feb 24, 2026
Clinical Trial
A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS)
Phase Phase 2 — ACTIVE_NOT_RECRUITING