AXSM

Axsome Therapeutics, Inc.

Nasdaq · Pharmaceutical Preparations · Inc. DE · CIK 0001579428
$255.17 +0.55% $13.1B
Insider Selling Cluster (5 insiders)High Impact Filing (7/10)25 New Institutional Positions12 Institutional Exits
Vol
Market Cap$13.1B
Cap SizeLarge Cap
Analyst ConsensusStrong Buy (93%)
Inst. Holders50 funds
Inst. Value$4.2B
Inst. Activity25 buys / 12 sells
Insider Activity0B / 15S
Insider Net $-$36.9M
Reddit Sentiment50° Neutral
SEC Reports12
Press Releases3
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. DE·CIK 0001579428·Prev Close $253.77

Recent Activity

Jun 12, 2026 SEC
A cluster of insider sales at Axsome Therapeutics (AXSM) over the past week totaled ~$20.2M in open-market transactions,
CLUSTER — Impact 4/10
Jun 11, 2026 SEC
Director Roger Jeffs filed a Form 144 to sell 286 shares of Axsome Therapeutics common stock, valued at approximately $7
144 — Impact 1/10
Jun 11, 2026 SEC
CEO Herriot Tabuteau and CFO Nick Pizzie sold a combined ~$19.9M in open-market sales on June 9, 2026, following derivat
CLUSTER — Impact 4/10
Jun 11, 2026 Insider
JEFFS ROGER sold 286 shares
Director @ $249.12 ($71.2K)
Jun 10, 2026 Insider
Coleman Mark sold 643 shares
Director @ $249.00 ($160.1K)
Jun 10, 2026 Insider
Mahony Susan sold 300 shares
Director @ $246.18 ($73.9K)
Inst.
FMR LLC — ADD
1,566,995 shares ($264.9M)
Inst.
Assenagon Asset Management S.A. — ADD
865,958 shares ($146.4M)

Price Targets

$275.28 +7.9% upside Buy
Current $255.17 Low $200.00 Median $272.00 High $380.00 21 analysts
$200.00 $380.00

Analyst Ratings

Strong Buy93% buy · 27 analysts
10Strong Buy
15Buy
2Hold
0Sell
0Strong Sell
Recent Analyst Actions
DateFirmActionRating
May 5, 2026 Morgan Stanley MAINTAIN Equal-Weight → Equal-Weight
May 5, 2026 RBC Capital MAINTAIN Outperform → Outperform
May 5, 2026 Wells Fargo MAINTAIN Overweight → Overweight
May 5, 2026 Guggenheim MAINTAIN Buy → Buy
May 5, 2026 Mizuho MAINTAIN Outperform → Outperform

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $-0.82 ▲ +6.2% $-1.21 — $-0.05 16% YoY 8
Next Q $-0.34 ▲ +28.5% $-0.77 — $0.62 64% YoY 8
Current FY $-1.71 ▲ +30.2% $-3.35 — $1.30 51% YoY 8
Next FY $5.89 ▲ +20.4% $1.63 — $12.53 445% YoY 9

Top Institutional Holders

FundValueMove
NOMURA ASSET MANAGEMENT CO
BlackRock, Inc.$661.3M
VANGUARD PORTFOLIO MANAGEMENT LLC$347.9M
VANGUARD CAPITAL MANAGEMENT LLC$327.5M
FMR LLC$264.9MADD

Recent Insider Trades

DateInsiderTypeValue
Jun 11, 2026JEFFS ROGERSELL$71.2K
Jun 10, 2026Coleman MarkSELL$160.1K
Jun 10, 2026Mahony SusanSELL$73.9K
Jun 10, 2026JEFFS ROGERSELL$70.4K
Jun 9, 2026TABUTEAU HERRIOTM$245.9K

Reddit Sentiment

50°
Neutral
Bearish Neutral Bullish
2 mentions 0 bullish 0 bearish
50 institutional holders with $4.2B total value (25,028,884 shares) as of 2026-Q1. Top holders: NOMURA, BlackRock,, VANGUARD. Net buying activity: 25 institutions added/increased vs 12 reduced.

Top Institutional Holders — 2026-Q1

#FundSharesValue% of TrackedLast Move
1NOMURA ASSET MANAGEMENT CO LTD$0.000.0%
2BlackRock, Inc.3,912,844$661.3M15.6%
3VANGUARD PORTFOLIO MANAGEMENT LLC2,058,170$347.9M8.2%
4VANGUARD CAPITAL MANAGEMENT LLC1,937,752$327.5M7.7%
5FMR LLC1,566,995$264.9M6.3%ADD +32.6%
6Invesco Ltd.1,297,678$219.3M5.2%ADD +28.6%
7WELLINGTON MANAGEMENT GROUP LLP1,145,306$193.6M4.6%
8STATE STREET CORP986,809$166.8M3.9%
9Assenagon Asset Management S.A.865,958$146.4M3.5%ADD +85.0%
10NOMURA ASSET MANAGEMENT INTERNATIONAL INC.812,809$137.4M3.2%
11ADAGE CAPITAL PARTNERS GP, L.L.C.737,578$124.7M2.9%DOUBLED +100.7%
12D. E. Shaw & Co., Inc.603,465$102.0M2.4%ADD +85.3%
13BANK OF AMERICA CORP /DE/598,091$101.1M2.4%ADD +71.1%
14FIRST TRUST ADVISORS LP577,479$97.6M2.3%DOUBLED +1230.2%
15MORGAN STANLEY476,701$80.6M1.9%
16FRANKLIN RESOURCES INC438,490$74.1M1.8%ADD +28.0%
17Point72 Asset Management, L.P.424,750$71.8M1.7%DOUBLED +2259.9%
18GOLDMAN SACHS GROUP INC421,447$71.2M1.7%
19Pictet Asset Management Holding SA415,983$70.3M1.7%
20CHARLES SCHWAB INVESTMENT MANAGEMENT INC395,118$66.8M1.6%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
FMR LLCADD1,181,6221,566,995+32.6%$264.9M2026-Q1
Assenagon Asset Management S.A.ADD467,982865,958+85.0%$146.4M2026-Q1
ADAGE CAPITAL PARTNERS GP, L.L.C.DOUBLED367,578737,578+100.7%$124.7M2026-Q1
FIRST TRUST ADVISORS LPDOUBLED43,413577,479+1230.2%$97.6M2026-Q1
FRANKLIN RESOURCES INCADD342,573438,490+28.0%$74.1M2026-Q1
Point72 Asset Management, L.P.DOUBLED17,999424,750+2259.9%$71.8M2026-Q1
DRIEHAUS CAPITAL MANAGEMENT LLCADD220,518292,370+32.6%$49.4M2026-Q1
FRONTIER CAPITAL MANAGEMENT CO LLCADD157,691203,066+28.8%$34.3M2026-Q1
AMERIPRISE FINANCIAL INCADD99,916176,314+76.5%$29.8M2026-Q1
1832 Asset Management L.P.DOUBLED13,700143,800+949.6%$24.3M2026-Q1
MARSHALL WACE, LLPTRIM320,568141,236-55.9%$23.9M2026-Q1
Connor, Clark & Lunn Investment Management Ltd.TRIM188,258134,792-28.4%$22.8M2026-Q1
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUNDNEW97,550$16.5M2026-Q1
SEI INVESTMENTS COADD47,60070,064+47.2%$11.8M2026-Q1
HSBC HOLDINGS PLCNEW68,453$11.6M2026-Q1
HB Wealth Management, LLCADD34,10250,237+47.3%$8.5M2026-Q1
STATE OF WISCONSIN INVESTMENT BOARDADD26,60340,381+51.8%$6.8M2026-Q1
TD ASSET MANAGEMENT INCTRIM41,97227,132-35.4%$4.6M2026-Q1
PRUDENTIAL FINANCIAL INCDOUBLED5,41524,573+353.8%$4.2M2026-Q1
JANUS HENDERSON GROUP PLCADD15,10419,052+26.1%$3.2M2026-Q1
BLAIR WILLIAM & CO/ILTRIM46,84016,308-65.2%$2.8M2026-Q1
FIFTH THIRD BANCORPDOUBLED2,47716,214+554.6%$2.7M2026-Q1
CWM, LLCADD5,1497,734+50.2%$1.3M2026-Q1
&PARTNERSDOUBLED1,6026,137+283.1%$1.0M2026-Q1
Trexquant Investment LPNEAR_EXIT49,1365,935-87.9%$1.0M2026-Q1
9 unique insiders with 43 transactions. Net insider value: -$36.9M ($0.00 bought, $36.9M sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 11, 2026JEFFS ROGERDirectorSELL286$249.12$71.2K
Jun 10, 2026Coleman MarkDirectorSELL643$249.00$160.1K
Jun 10, 2026Mahony SusanDirectorSELL300$246.18$73.9K
Jun 10, 2026JEFFS ROGERDirectorSELL286$246.18$70.4K
Jun 9, 2026TABUTEAU HERRIOTChief Executive OfficerEXERCISE49,670$4.95$245.9K
Jun 9, 2026Pizzie NickChief Financial OfficerEXERCISE33,000$3.50$115.5K
Jun 9, 2026Pizzie NickChief Financial OfficerSELL33,000$240.09$7.9M
Jun 9, 2026TABUTEAU HERRIOTChief Executive OfficerSELL49,670$241.01$12.0M
Jun 9, 2026Mahony SusanDirectorSELL300$237.21$71.2K
Jun 8, 2026Coleman MarkDirectorEXERCISE1,429
Jun 8, 2026Mahony SusanDirectorEXERCISE1,429
Jun 8, 2026JEFFS ROGERDirectorEXERCISE1,429
Jun 8, 2026Saad Mark EDirectorEXERCISE1,429
Jun 5, 2026Coleman MarkDirectorAWARD1,721
Jun 5, 2026Mahony SusanDirectorAWARD1,721
Jun 5, 2026Saad Mark EDirectorAWARD1,721
Jun 5, 2026JEFFS ROGERDirectorAWARD1,721
Jun 2, 2026Coleman MarkDirectorSELL5,537$223.39$1.2M
Jun 1, 2026Coleman MarkDirectorSELL6,000$230.30$1.4M
May 29, 2026Coleman MarkDirectorSELL6,000$233.46$1.4M
May 5, 2026Jacobson Mark L.Chief Operating OfficerSELL233$228.18$53.2K
May 5, 2026Jacobson Mark L.Chief Operating OfficerEXERCISE233$12.95$3.0K
May 4, 2026Jacobson Mark L.Chief Operating OfficerSELL4,517$227.94$1.0M
May 4, 2026Jacobson Mark L.Chief Operating OfficerEXERCISE4,517$12.95$58.5K
Apr 22, 2026Maizel AriChief Commercial OfficerEXERCISE7,500$70.73$530.5K
Apr 22, 2026Maizel AriChief Commercial OfficerSELL7,500$182.42$1.4M
Apr 21, 2026Murdock Hunter R.General CounselAWARD7,224
Apr 21, 2026Pizzie NickChief Financial OfficerAWARD8,188
Apr 21, 2026Maizel AriChief Commercial OfficerAWARD7,224
Apr 21, 2026TABUTEAU HERRIOTChief Executive OfficerAWARD24,081
Apr 21, 2026Jacobson Mark L.Chief Operating OfficerAWARD8,669
Feb 26, 2026Jacobson Mark L.Chief Operating OfficerAWARD19,663
Feb 26, 2026TABUTEAU HERRIOTChief Executive OfficerAWARD54,623
Feb 26, 2026Maizel AriChief Commercial OfficerAWARD16,385
Feb 26, 2026Murdock Hunter R.General CounselAWARD16,385
Feb 26, 2026Pizzie NickChief Financial OfficerAWARD18,570
Feb 26, 2026Jacobson Mark L.Chief Operating OfficerEXERCISE35,378$2.85$100.8K
Feb 26, 2026Coleman MarkDirectorSELL25,000$161.11$4.0M
Feb 23, 2026Coleman MarkDirectorEXERCISE6,250$4.95$30.9K
Feb 20, 2026Coleman MarkDirectorEXERCISE12,485$4.95$61.8K
Feb 10, 2026Coleman MarkDirectorEXERCISE5,193$8.02$41.6K
Feb 2, 2026TABUTEAU HERRIOTChief Executive OfficerEXERCISE32,410$8.02$259.9K
Feb 2, 2026TABUTEAU HERRIOTChief Executive OfficerSELL32,410$185.60$6.0M
12 SEC filing reports analyzed. Sentiment: 2 bullish, 0 bearish, 2 mixed, 8 neutral. Avg impact: 4.3/10.
NEUTRAL CLUSTER 4/10
A cluster of insider sales at Axsome Therapeutics (AXSM) over the past week totaled ~$20.2M in open-
Jun 12, 2026
NEUTRAL 144 1/10
Director Roger Jeffs filed a Form 144 to sell 286 shares of Axsome Therapeutics common stock, valued
Jun 11, 2026
NEUTRAL CLUSTER 4/10
CEO Herriot Tabuteau and CFO Nick Pizzie sold a combined ~$19.9M in open-market sales on June 9, 202
Jun 11, 2026
NEUTRAL 144 4/10
CEO Herriot Tabuteau files Form 144 to sell 49,670 shares of Axsome Therapeutics (~$12.2M) under a 1
Jun 9, 2026
NEUTRAL 8-K 2/10
Axsome Therapeutics adopted a formal Executive Severance and Change in Control Plan effective June 5
Jun 9, 2026
NEUTRAL CLUSTER 4/10
CEO Herriot and CFO Pizzie exercised stock options and immediately sold the resulting shares in open
Jun 9, 2026
BULLISH 8-K 7/10
Axsome settled all SUNOSI patent litigation, granting five generic companies entry rights no earlier
Jun 3, 2026
MIXED 8-K 6/10
Axsome reported Q1 2026 revenue of $191.2M (+57% YoY), slightly above the $190.7M consensus, but net
May 4, 2026
MIXED PRESS-RELEASE 6/10
Axsome reported Q1 2026 revenue of $191.2M (57% YoY growth, slight beat vs $190.7M consensus), but G
May 4, 2026
BULLISH 8-K 8/10
Axsome Therapeutics announced FDA approval of AUVELITY for agitation associated with dementia due to
Apr 30, 2026
NEUTRAL DEFA14A 2/10
Axsome Therapeutics is holding its 2026 annual meeting for shareholders to vote on director election
Apr 24, 2026
NEUTRAL PRESS-RELEASE 3/10
Axsome Therapeutics announced it will report Q1 2026 financial results on May 4, 2026, followed by a
Apr 8, 2026
Current analyst consensus: Strong Buy (93% buy). Based on 27 analysts: 10 strong buy, 15 buy, 2 hold, 0 sell, 0 strong sell.

Analyst Price Targets

$275.28 mean target +7.9% upside Buy (1.24)
$200.00 Low $380.00 High
MetricValue
Current Price$255.17
Target Low$200.00
Target Mean$275.28
Target Median$272.00
Target High$380.00
# Analysts21
RecommendationBuy (1.24)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$-0.82 $-1.21 $-0.05 15.7% +6.2% 1↑ 3↓ $0.2B 48.2% 8
Next Q
2026-09-30
$-0.34 $-0.77 $0.62 64.4% +28.5% 0↑ 4↓ $0.3B 53.8% 8
Current FY
2026-12-31
$-1.71 $-3.35 $1.30 50.9% +30.2% 1↑ 5↓ $1.0B 54.4% 8
Next FY
2027-12-31
$5.89 $1.63 $12.53 445.1% +20.4% 3↑ 2↓ $1.6B 62.1% 9

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$-0.818
7d ago$-0.818
30d ago$-0.872+0.054
60d ago$-0.554-0.263
90d ago$-0.554-0.263
13 analyst firms have rated this stock: 0 upgrades, 1 downgrades, 1 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
May 5, 2026 Morgan Stanley MAINTAIN Equal-Weight Equal-Weight
May 5, 2026 RBC Capital MAINTAIN Outperform Outperform
May 5, 2026 Wells Fargo MAINTAIN Overweight Overweight
May 5, 2026 Guggenheim MAINTAIN Buy Buy
May 5, 2026 Mizuho MAINTAIN Outperform Outperform
May 5, 2026 Baird MAINTAIN Outperform Outperform
May 5, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
May 5, 2026 Needham MAINTAIN Buy Buy
May 4, 2026 Jefferies MAINTAIN Buy Buy
May 4, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
May 1, 2026 Needham MAINTAIN Buy Buy
Apr 10, 2026 UBS MAINTAIN Buy Buy
Mar 25, 2026 Guggenheim MAINTAIN Buy Buy
Feb 24, 2026 UBS MAINTAIN Buy Buy
Feb 24, 2026 Guggenheim MAINTAIN Buy Buy
Feb 24, 2026 RBC Capital MAINTAIN Outperform Outperform
Feb 24, 2026 Wells Fargo MAINTAIN Overweight Overweight
Feb 24, 2026 Wolfe Research INITIATE Outperform
Feb 23, 2026 Needham REITERATE Buy Buy
Feb 3, 2026 Jefferies MAINTAIN Buy Buy
Jan 28, 2026 Leerink Partners MAINTAIN Outperform Outperform
Jan 21, 2026 RBC Capital MAINTAIN Outperform Outperform
Jan 20, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Jan 16, 2026 Piper Sandler MAINTAIN Overweight Overweight
Jan 13, 2026 Wells Fargo MAINTAIN Overweight Overweight
Jan 8, 2026 Morgan Stanley DOWNGRADE Overweight Equal-Weight
Jan 6, 2026 UBS MAINTAIN Buy Buy
Jan 5, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Dec 31, 2025 Needham MAINTAIN Buy Buy

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 2026101520093%
May 1, 2026101520093%
Apr 1, 202691520092%
Mar 1, 202691520092%
Feb 1, 202691520092%
Jan 1, 202691610096%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

50°
Neutral
Bearish Neutral Bullish
2 mentions 0 bullish 0 bearish 2 time periods

Reddit Sentiment History

DateMentionsSentimentBullishBearishThreads
Apr 16, 2026144° Neutral001
Apr 16, 2026144° Neutral001

Recent Reddit Threads

r/wallstreetbets Neutral 1mo ago
Why is no one talking about $AXSM?
▲ 1 💬 1 ⚡ 0.5
Jun 4, 2026
fda
Axsome Therapeutics Presents New SYMBRAVO® Data at the Americal Headache Society (AHS) 68th Annual Scientific Meeting
<p align="justify">NEW YORK, June 04, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new e
Jun 1, 2026
contract
Axsome Therapeutics Partners with the Headache Alliance to Highlight the Impact of Migraine During Migraine and Headache Awareness Month
<p align="justify">NEW YORK, June 01, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new e
Jun 1, 2026
FDA
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients i
May 29, 2026
Clinical Trial
A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy
Phase Phase 3 — COMPLETED
May 27, 2026
other
Axsome Therapeutics to Participate in Upcoming Investor Conferences
<p align="justify">NEW YORK, May 27, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new er
May 13, 2026
short_interest
FTD: AXSM — 57,815 shares ($13.0M) failed to deliver
Settlement: 20260513, Price: $224.03, FTD Value: $12,952,294.45, AXSOME THERAPEUTICS INC COM ST
May 12, 2026
short_interest
FTD: AXSM — 39,641 shares ($8.6M) failed to deliver
Settlement: 20260512, Price: $216.47, FTD Value: $8,581,087.27, AXSOME THERAPEUTICS INC COM ST
May 11, 2026
short_interest
FTD: AXSM — 62,981 shares ($13.7M) failed to deliver
Settlement: 20260511, Price: $217.38, FTD Value: $13,690,809.78, AXSOME THERAPEUTICS INC COM ST
May 6, 2026
FDA
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients i
May 6, 2026
FDA
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients i
May 5, 2026
other
Axsome Therapeutics to Participate in Upcoming Investor Conferences
<p align="justify">NEW YORK, May 05, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new er
May 4, 2026
earnings
Axsome Therapeutics Reports First Quarter 2026 Financial Results and Provides Business Update
<p align="center"><em>Total 1Q 2026 net product revenue of $191.2 million, representing 57% year-over-year growth</em></p>
May 4, 2026
short_interest
FTD: AXSM — 13,914 shares ($2.9M) failed to deliver
Settlement: 20260504, Price: $206.53, FTD Value: $2,873,658.42, AXSOME THERAPEUTICS INC COM ST
May 4, 2026
earnings_calendar
AXSM Q1 2026 Earnings Scheduled — 2026-05-04
May 1, 2026
fda
Axsome Therapeutics Hosts AUVELITY® FDA Approval Investor Event Featuring Expert Thought Leader
<p align="justify">NEW YORK, May 01, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new er
Apr 30, 2026
fda
Axsome Therapeutics Announces FDA Approval of AUVELITY® (dextromethorphan HBr and bupropion HCl) for the Treatment of Agitation Associated with Dementia due to Alzheimer’s Disease
<p align="center"><em>AUVELITY is a first-in-class treatment, which targets the NMDA and sigma-1 receptors, approved for agitation associated with dem
Apr 30, 2026
fda_pdufa
PDUFA: AXSM — AXS-05 in Alzheimer's disease agitation — 2026-04-30
FDA target action date 2026-04-30 for AXSM (Axsome Therapeutics, Inc.). Drug: AXS-05. Indication: Alzheimer's disease agitation. sNDA for AXS-05 for A
Apr 30, 2026
FDA
AUVELITY
Supplemental Approval — Labeling — DEXTROMETHORPHAN HYDROBROMIDE, BUPROPION HYDROCHLORIDE — TABLET, EXTENDED RELEASE — ORAL
Apr 8, 2026
earnings
Axsome Therapeutics to Report First Quarter 2026 Financial Results on May 4
<p align="justify">NEW YORK, April 08, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new
Mar 11, 2026
short_interest
FTD: AXSM — 15,412 shares ($2.6M) failed to deliver
Settlement: 20260311, Price: $166.34, FTD Value: $2,563,632.08, AXSOME THERAPEUTICS INC COM ST