UPB Upstream Bio, Inc.

NEUTRAL Impact: 3/10 Insider Cluster (3 insiders)
Horizon days Filed Mar 16, 2026 Processed 2mo ago
Insider cluster: 2 insiders, $11K total
Latest settled — T+20d
UPB ▲ +7.60% at T+20d
NEUTRAL call ✓ call won +7.60% · α vs SPY +3.82% · entry $9.61 → $10.34
Next anchor: T+60d due 16h ago
Currently $6.69 · -30.39% from $9.61 entry
Entry anchored
Mar 13, 03:59 PM ET
via Databento tick
T+1d
+1.04%
call +1.04% · α +0.77%
$9.71
settled 3mo ago
T+5d
-12.07%
call -12.07% · α -10.03%
$8.45
settled 3mo ago
T+20d
+7.60%
call +7.60% · α +3.82%
$10.34
settled 8w ago
T+60d
call — · α —
due 16h ago

Price Chart

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Executive Summary

Three corporate insiders at Upstream Bio, Inc. (UPB) sold shares in a coordinated open-market transaction on March 16, 2026, including the CEO and Chief Business Officer. The total value of the sales was approximately $30,350, representing a small but notable insider selling cluster.

Key Financial Metrics

Direction
selling
Total Value
$30.4K
Insiders
3

Actionable Insight

Monitor for additional insider selling in the coming weeks; while this cluster is small in dollar value, the participation of the CEO and C-suite executives warrants attention ahead of upcoming earnings or clinical trial updates.

Key Facts

  • Chief Executive Officer Sutherland Everett Rand sold 2,093 shares for $19,443.97.
  • Chief Business Officer Adam Houghton sold 699 shares for $6,493.71.
  • General Counsel Allison Ambrose sold 475 shares for $4,412.75.
  • All transactions occurred on the same day (2026-03-16) in the open market at $9.29 per share.
  • Total value of insider sales: $30,350.53.

Financial Impact

$30,350 in open-market share sales by insiders

insider ownershipmarket sentiment

Risk Factors

  • Potential perception of lack of confidence if no offsetting buy activity follows.
  • Risk of negative sentiment if future filings reveal larger-scale selling or downward revisions to company outlook.

Market Snapshot

Exchange
Nasdaq

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CONTEXT: Insider Cluster Data (3 trades, 7d window)cluster-UPB-1773781280101
7 reports for UPB
Performance horizon
50% Hit rate 2 of 4 directional calls best @ T+5▲ +14.21%May 13, 2026
Filters
Rows
Reports for UPB — sortable, filterable
Type Now
May 18, 2026
22d ago
Press Release
BULLISH ★ 7/10
$8.51 $8.21▼ −3.53%▼ −5.14%$6.69 (−21.39%)
May 13, 2026
27d ago
Press Release
BEARISH ★ 6/10
$9.36 $8.03▲ +14.21%▲ +13.05%$6.69 (+28.53%)
Apr 17, 2026
7w ago
Press Release
NEUTRAL ★ 3/10
$9.99 $9.30▼ −6.91%▼ −7.46%$6.69 (−33.03%)
Mar 26, 2026
10w ago
424B5
BEARISH ★ 6/10
$8.67 $9.72▼ −12.11%▼ −8.25%$6.69 (+22.84%)
Mar 26, 2026
10w ago
Press Release
MIXED ★ 6/10
$9.79 $9.50▼ −2.96%▼ −4.60%$6.69 (−31.66%)
Mar 16, 2026
12w ago
Insider Cluster
NEUTRAL ★ 3/10
$9.61 $8.45▼ −12.07%▼ −10.03%$6.69 (−30.39%)
Mar 1, 2026
14w ago
Press Release
BULLISH ★ 8/10
$7.70 $8.06▲ +4.68%▲ +5.88%$6.69 (−13.12%)
Showing 7 of 7

US Market Status

Market Closed — Opens Thu (9h 47m)

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