SYRE Spyre Therapeutics, Inc.
Executive Summary
Four mega-passive institutional investors (Vanguard, BlackRock, State Street, Fidelity) collectively added $468.9M in SYRE during Q4 2025, increasing their combined holdings to $768.5M. The buying is dominated by index-fund rebalancing rather than active conviction, and the sole seller (Morgan Stanley) trimmed a small position. The cluster reflects passive index weight adjustments following SYRE's significant market cap growth, not a fundamental thesis change.
Key Financial Metrics
Institutional Positions
Net institutional flow: $468.9M
▲ Buyers (4)
| Institution | Action | Change | Position Value | Value Δ |
|---|---|---|---|---|
| Fidelity | ADD | +28.5% | $381.3M | $229.4M |
| BlackRock | ADD | +38.7% | $180.9M | $114.2M |
| Vanguard | ADD | +32.3% | $132.2M | $81.1M |
| State Street | ADD | +26.8% | $74.1M | $44.2M |
▼ Sellers (1)
| Institution | Action | Change | Prev Value | Value Δ |
|---|---|---|---|---|
| Morgan Stanley | TRIM | -45.4% | $5.6M | $376.0K |
Actionable Insight
This cluster is driven by passive index rebalancing, not active conviction. Monitor for active fund 13F filings in coming weeks to gauge genuine institutional interest. The 96% analyst bullish consensus and strong historical T+20 performance (78% win rate) suggest the stock has momentum, but this filing alone provides no new fundamental catalyst.
Key Facts
- 4 mega-passive funds added $468.9M in aggregate, bringing total holdings to $768.5M
- Fidelity led with a $229.4M increase (28.5% share growth), now holding $381.3M
- BlackRock added $114.2M (38.7% share growth), now at $180.9M
- Vanguard added $81.1M (32.3% share growth), now at $132.2M
- State Street added $44.2M (26.8% share growth), now at $74.1M
- Morgan Stanley trimmed 45.4% of its position but value increased $376K due to price appreciation
- All five funds are mega-passive/index managers — zero active or activist funds participated
- The cluster reflects passive index rebalancing, not active investment thesis
Financial Impact
4 passive funds accumulated $468.9M in new SYRE positions; 1 passive fund trimmed a small position with net value increase of $376K
Risk Factors
- All buyers are passive/index funds — no active manager signal to validate the thesis
- 13F data is 45+ days stale; positions may have been unwound since quarter-end
- Morgan Stanley's trim, while small, is the only non-buying signal in the cluster
Market Snapshot
Documents Analyzed
This report is based on 1 institutional 13F filing from SEC EDGAR.
| Document | Accession Number |
|---|---|
| INST-CLUSTER Data (Synthetic) | inst-cluster-SYRE-2025-Q4 |
Filters
| Type | Now | ||||
|---|---|---|---|---|---|
|
Jun 12, 2026
3d ago
|
Institutional Cluster
| $81.50 awaiting T+1 | awaiting T+1 | — | — |
|
Jun 11, 2026
4d ago
|
Institutional Cluster
| $76.50 awaiting T+1 | awaiting T+1 | — | — |
|
Jun 4, 2026
11d ago
|
Insider Cluster
| $78.48 $73.65 | ▼ −6.15% | ▼ −3.56% | — |
|
Jun 1, 2026
13d ago
|
8-K
| $69.16 $73.52 | ▲ +6.30% | ▲ +7.00% | — |
|
May 29, 2026
16d ago
|
8-K
| $70.54 $69.16 | ▼ −1.96% | ▼ −2.10% | — |
|
May 5, 2026
5w ago
|
8-K
| $71.01 $73.00 | ▲ +2.80% | ▲ +1.42% | — |
|
May 1, 2026
6w ago
|
Insider Cluster
| $69.42 $69.13 | ▼ −0.42% | ▼ −0.08% | — |
|
May 1, 2026
6w ago
|
Insider Cluster
| $69.42 $69.13 | ▼ −0.42% | ▼ −0.08% | — |
|
Apr 15, 2026
8w ago
|
Press Release
| $68.99 $69.70 | ▲ +1.03% | ▲ +0.78% | — |
|
Apr 13, 2026
8w ago
|
424B5
| $64.01 $68.99 | ▲ +7.78% | ▲ +7.01% | — |
US Market Status
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