SYRE Spyre Therapeutics, Inc.

NEUTRAL Impact: 2/10 Insider Cluster (2 insiders)
Horizon days Filed Jun 4, 2026 Processed 9d 7h ago
Insider cluster: 2 insiders, $372K total
Latest settled — T+1d ⚠ clustered
SYRE ▼ -6.15% at T+1d
NEUTRAL call ✗ call lost -6.15% · α vs SPY -3.56% · entry $78.48 → $73.65
Next anchor: T+5d due 3d ago
Currently $80.79 · +2.94% from $78.48 entry
Entry anchored
Jun 3, 2026
via day open
T+1d
-6.15%
call -6.15% · α -3.56%
$73.65
settled 9d ago
T+5d
call — · α —
due 3d ago
T+20d
call — · α —
in 19d
T+60d
call — · α —
in 3mo

Price Chart

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Executive Summary

CEO Turtle Cameron and CFO Scott Burrows sold a combined $372K in SYRE stock on June 1, 2026, at ~$69.40-$69.75. The CFO also exercised options for $108,750 and had shares withheld for taxes (non-cash). At a $6.4B market cap, the sales represent ~0.006% of market cap — trivial in size and consistent with routine portfolio diversification or tax planning. The cluster is not informative given the small dollar amounts and the CFO's concurrent option exercise.

Key Financial Metrics

Direction
selling
Total Value
$372.0K
Insiders
2

Actionable Insight

Insider sales are immaterial in size and likely liquidity-driven (CFO exercised options and sold a portion to cover taxes). No bearish signal. Monitor for any material insider purchases or larger sales (>$5M) that would indicate a change in sentiment.

Key Facts

  • CEO sold 3,557 shares for $247K at $69.40
  • CFO sold 1,801 shares for $126K at $69.75
  • CFO exercised 7,500 options at $14.50 for $108,750 (non-cash exercise)
  • Total open-market sales: $372K, representing ~0.006% of $6.4B market cap
  • No insider purchases in the cluster

Financial Impact

Total insider sales of $372K are negligible relative to $6.4B market cap (0.006%). CFO's option exercise is a non-cash event with no economic impact.

insider holdingsdilution

Risk Factors

  • Insider sales, while small, could precede negative news if they accelerate in size or frequency
  • CFO's option exercise adds 7,500 shares to the float, but the net dilution is negligible

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
96% bullish (23 analysts)

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SYRE-1780536706609
18 reports for SYRE
Performance horizon
83% Hit rate 5 of 6 directional calls best @ T+20▲ +20.80%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
Type Now
Jun 12, 2026
today
Institutional Cluster
BULLISH ★ 6/10
$81.50 awaiting T+1awaiting T+1$80.79 (−0.87%)
Jun 11, 2026
1d ago
Institutional Cluster
NEUTRAL ★ 3/10
$76.50 awaiting T+1awaiting T+1$80.79 (+5.61%)
Jun 4, 2026
9d ago
Insider Cluster
NEUTRAL ★ 2/10
$78.48 $73.65▼ −6.15%▼ −3.56%$80.79 (+2.94%)
Jun 1, 2026
11d ago
8-K
BULLISH ★ 7/10
$69.16 $73.52▲ +6.30%▲ +7.00%$80.79 (+16.82%)
May 29, 2026
14d ago
8-K
NEUTRAL ★ 3/10
$70.54 $69.16▼ −1.96%▼ −2.10%$80.79 (+14.53%)
May 5, 2026
5w ago
8-K
MIXED ★ 6/10
$71.01 $73.00▲ +2.80%▲ +1.42%$80.79 (+13.77%)
May 1, 2026
6w ago
Insider Cluster
NEUTRAL ★ 3/10
$69.42 $69.13▼ −0.42%▼ −0.08%$80.79 (+16.38%)
May 1, 2026
6w ago
Insider Cluster
NEUTRAL ★ 2/10
$69.42 $69.13▼ −0.42%▼ −0.08%$80.79 (+16.38%)
Apr 15, 2026
8w ago
Press Release
NEUTRAL ★ 6/10
$68.99 $69.70▲ +1.03%▲ +0.78%$80.79 (+17.10%)
Apr 13, 2026
8w ago
424B5
BULLISH ★ 8/10
$64.01 $68.99▲ +7.78%▲ +7.01%$80.79 (+26.21%)
Showing 10 of 18

US Market Status

Market Closed — Opens Mon (52h 15m)

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