AAPG ASCENTAGE PHARMA GROUP INTERNATIONAL
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Executive Summary
Ascentage Pharma presented 17 clinical updates at the EHA2026 Congress, including data from its two core assets olverembatinib and lisaftoclax. Key highlights include statistically significant MMR rates vs. control in CML (54.3% vs 10.0% at 6 months, P<0.001), strong POLARIS-1 Ph+ ALL registrational Phase III results (94.4% CR/CRi, 93.1% MRD-negativity by cycle 9), and promising chemotherapy-free pediatric Ph+ ALL data (ORR 88.9%). The data support label expansion for olverembatinib into second-line CML without T315I and validate lisaftoclax's real-world utility in AML. No financial figures were disclosed.
Actionable Insight
Positive clinical data at a major medical congress (EHA) supports the fundamental thesis for both olverembatinib and lisaftoclax label expansion. Watch for FDA/EMA interactions on potential label updates for olverembatinib in CML second-line and Ph+ ALL. The chemotherapy-free pediatric combination is a novel data point that de-risks the pipeline. No near-term binary catalyst (e.g., PDUFA date or enrollment completion) announced in this filing.
Key Facts
- 17 clinical updates presented at EHA2026, including 8 posters
- Olverembatinib: 6-month MMR 54.3% vs 10.0% (P<0.001) in CML-CP patients who failed at least 2 prior TKIs
- Olverembatinib: CR/CRi 94.4%, MRD-negativity 93.1% by cycle 9 in Ph+ ALL (POLARIS-1 registrational Phase III)
- Lisaftoclax: real-world AML CR/CRi 72%, MRD-negativity 61% (N=25)
- Pediatric Ph+ ALL combination (olverembatinib + lisaftoclax): ORR 88.9%, MRD-negativity 66.7%
- Lisaftoclax in BTKi-refractory CLL/SLL: median PFS 23.9 months, ORR 62.5%
- Olverembatinib remains FDA- and EMA-cleared in three global registrational trials (POLARIS-1, 2, 3)
- Lisaftoclax has 4 ongoing global registrational Phase III trials (GLORA, GLORA-2, GLORA-3, GLORA-4)
Financial Impact
No financial figures disclosed in the filing. Clinical data supports potential label expansion for both core assets, which could materially expand the addressable market for olverembatinib into second-line CML and lisaftoclax into AML and pediatric ALL.
Risk Factors
- Both drugs have not yet received US FDA approval—approval risk remains
- China NRDL pricing pressure could limit commercial upside
- Competition from approved Bcl-2 inhibitors (venetoclax) and third-gen TKIs (asciminib) in global markets
Market Snapshot
Documents Analyzed
This report is based on 6 SEC documents filed with EDGAR.
| Document | Accession Number |
|---|---|
| 6-K Filing (Primary) | 0001213900-26-068502 |
| Document: ea029473801ex99-2.htm | 0001213900-26-068502 |
| Document: ea0294738-6k_ascentage.htm | 0001213900-26-068502 |
| Document: 0001213900-26-068502-index-headers.html | 0001213900-26-068502 |
| Document: 0001213900-26-068502-index.html | 0001213900-26-068502 |
| Document: 0001213900-26-068502.txt | 0001213900-26-068502 |
Track record builds as more directional reports settle.
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Jun 15, 2026
3d ago
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6-K
| $17.34 $17.01 | ▼ −1.90% | ▼ −1.31% | $17.09 (−1.44%) |
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Jun 14, 2026
4d ago
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Press Release
| $17.34 $17.01 | ▼ −1.90% | ▼ −1.31% | $17.09 (−1.44%) |
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Jun 1, 2026
17d ago
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6-K
| $19.08 $18.45 | ▼ −3.30% | ▼ −3.45% | $17.09 (−10.43%) |
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May 28, 2026
21d ago
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| $20.01 $19.08 | ▼ −4.65% | ▼ −4.91% | $17.09 (−14.59%) |
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May 28, 2026
21d ago
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| $19.88 $20.01 | ▲ +0.65% | ▲ +0.41% | $17.09 (−14.03%) |
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May 22, 2026
27d ago
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6-K
| $21.01 $20.13 | ▼ −4.20% | ▼ −4.79% | $17.09 (−18.66%) |
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May 22, 2026
28d ago
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Press Release
| $21.01 $20.13 | ▼ −4.20% | ▼ −4.79% | $17.09 (−18.66%) |
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May 13, 2026
5w ago
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6-K
| $21.38 $20.18 | ▼ −5.61% | ▼ −6.39% | $17.09 (−20.07%) |
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May 12, 2026
5w ago
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6-K
| $21.16 $21.38 | ▲ +1.04% | ▲ +0.46% | $17.09 (−19.23%) |
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Apr 22, 2026
8w ago
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6-K
| $25.13 $22.34 | ▼ −11.10% | ▼ −10.71% | $17.09 (−31.99%) |
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